Full Spectrum CBD Oil Questions

There is not a significant amount of research in humans to identify the effects of consuming alcohol alongside CBD. 

The research that has been done (mostly in animals, such as mice) has identified that CBD may protect against alcohol induced cell damage while reducing blood alcohol concentrations (“What Happens If You Mix CBD and Alcohol”). This is not to say that taking CBD makes consuming a higher amount of alcohol safe, both of these substances should be consumed in moderation. Both CBD and alcohol have a sedation effect on the body and when taken together, these substances may amplify each other (“What Happens If You Mix CBD and Alcohol”). This amplification could make the consumer significantly impaired.

Terpenes are aromatic compounds found in plants, creating the fragrance found in plants like Lavender, pine, and hemp. These are the same compounds found in essential oils. Terpenes are beneficial for the plants as they either attract or repel insects. Attracting pollinators is crucial to the reproduction of many plant species and the same goes for keeping predators away. 

Studies have shown that terpenes may have many different beneficial properties (depending on the type of terpene). Ingesting or smelling these terpenes may have some of the following benefits in humans:

 

Anti-inflammatory

Antioxidant

Antiviral

Antidiabetic

Anticancer

Antimicrobial

Antidepressant

Neuroprotective

Antianxiety

(“What to know about terpenes,” 2020)

There are many different types of Terpenes and each varies in its terpene concentration and potential benefits. Research is continuing to be done to discover the wide variety of health benefits related to terpenes.

The color of CBD oil is dependent on a couple of factors and generally is a good way to tell what quality of product you are buying / looking at. CBD oil can range from a light gold color to an almost black or dark brown color. Generally speaking the darker the color, the more concentrated the product is. CBD Isolate or CBD by itself is an almost clear color. Full-spectrum CBD oil is a darker color as it is a more concentrated hemp extract. 

Factors affecting the color include the carrier oil, additional ingredients, and the methods of extraction. Additional ingredients tend to include added flavors which vary from brand to brand as well as different products within one brand. Some methods of extraction include, CO2 extraction, Steam distillation, hydrocarbon solvent extraction, and natural solvent extraction. 

Laura’s Mercantile CBD oil is golden in color and our product is as close to the natural plant as possible, meaning that they are full spectrum and contain the maximum amount of benefits. 

There are several factors that play into how long CBD will remain in your system including metabolism, BMI, frequency of CBD use, CBD dosage, and method of administration (sublingual vs. topical vs. edible). A slower metabolism will mean that it will take longer for the CBD to leave the system. The food in your digestive system at the time of ingestion can also affect the bioavailability in your body, meaning that certain foods can increase the absorption of CBD.

 Sublingual ingestion (placing a dose under the tongue) is considered to be more effective than ingestion. “Effective” in this scenario means a higher amount of absorption in a shorter period of time. 

There is still not enough research regarding the toxicology of CBD and how long it is detectable in blood or urine. Existing research indicates that CBD will most likely leave the system within 1-2 weeks. 

The FDA has not approved CBD oils at this time. But, the leadership at Laura’s Mercantile is currently working with the staff of Kentucky’s congressional delegation. Specifically, we are working with U.S. Senate Majority Leader McConnell’s staff to work with the FDA in order to follow policies and procedures for Laura’s Homestead Alternatives to be FDA compliant. 

We know now that SARS-CoV2 is spread through respiratory droplets produced when an infected person sneezes, coughs, shouts, talks expressively or sings. Since the early days of the pandemic, the air-borne nature of the virus has become clearer, and we’ve been instructed to wear masks when in public.

One idea floating around the hemp CBD community comes from a paper titled “In Search of Preventative Strategies: Novel Anti-inflammatory High CBD Cannabis Sativa Extracts Modulate ACE2 Expression in COVID-19 Gateway Tissues.” The basic idea is that COVID enters the body through the mouth or nose by binding with ACE2 receptors there. Since cannabinoids also bind with ACE2, theoretically they should block entry of the COVID virus. 

The paper and comments can be reviewed here.

There is one pre-publication review, written by Jordan Curl, who is a former Marine turned cannabis consultant, which I expect aims in the right direction. Here it is in its entirety:

“It is very interesting that this organization points out this was a high CBD extract from a chemovar of cannabis SATIVA. They say they screened 1000s of plants of which only a few had that characteristic. My guess is that they found some phenotype higher in “minor” cannabinoids and don’t want to say. Look at the analytics and they show THC/CBD only. Aside from being a blatant advertising plug, it also doesn’t factor in terpene content or other cannabinoids which are known to have synergistic effects together with THC and CBD.”

Curl is referring to the entourage effect, which we at Laura’s Homestead Alternatives think likely is a powerful one. Read more about the science here.

Because of this, we at Laura’s Homestead Alternatives only produce full-spectrum CBD, extracted from USDA-Certified, Mt. Folly grown organic hemp. Hemp plants contain more than 100 cannabinoids and terpenes. We trust the plant, trust nature, and are not trying to patent nature either!

Product Questions

No. Laura’s Hemp Chocolates contain zero CBD or THC. The chocolates are made with organic hemp hearts, nutty grain kernels which are the seeds of a particular variety of hemp plant, along with dried cranberries, dark chocolate, and raspberry.

We use supercritical CO2 extraction, which is among the safest, cleanest methods to extract plant compounds.

Full spectrum CBD stays as close to the plant as possible, which means the product contains many cannabinoids beyond CBD, along with other compounds of the cannabis or hemp plant, like naturally-occurring terpenes, essential vitamins, fatty acids, proteins, and more.

CBD isolate is what it sounds like – the CBD is chemically isolated from other parts of the plant and results in a powder substance. Isolate products contain no traceable amount of THC and are stripped of other compounds of the cannabis or hemp plant.

Researchers in a 2015 study conducted at the Hebrew University of Jerusalem’s Hadassah School concluded full spectrum CBD was more effective at treating inflammation than CBD isolate, on the basis that other components in the full spectrum extract synergized with CBD in what has been dubbed “The Entourage Effect.”

See a more detailed explanation on our blog: What Full Spectrum CBD Means and Why It’s Important

There are three common ways to take CBD: orally, sublingually, or topically.

Orally:

Taking CBD orally is often in the form of capsules, or softgels. This is just like taking any other over-the-counter pill and can make it easier to monitor your dosage since capsules are pre-measured. However, a 2009 study reported CBD taken orally resulted in only a 4% to 20% bioavailability rate (the rate at which a substance is absorbed into the bloodstream). This means if you were to take 100mg of CBD, only about 4-20mg will reach your bloodstream.

Sublingually:

Sublingually is best when you’re using CBD oil. When taking CBD oil sublingually, you’ll place the oil under your tongue and hold it there for about 90 seconds. This allows your saliva to dissolve the oil, which then passes into your bloodstream. Since this method bypasses your digestive system, CBD taken sublingually has a higher bioavailability rate. Reported rates range from 12-25%.

Aside from our CBD oil, you can try Homestead Alternatives CBD Caramels – best eaten slowly to allow the candy to dissolve and CBD to be absorbed by your saliva glands.

Topically:

Another method of experiencing CBD is topically, which is said to be good for targeting specific parts of your body to relieve joint pain or aching muscles. CBD topicals come in the form of creams and lotions.

Full spectrum CBD products are the most beneficial for your body to consume due to the entourage effect created by the full spectrum of ingredients. An entourage effect describes the combination of ingredients working together giving the body an opportunity to redeem the full benefits of the CBD product.

 Full spectrum CBD products do contain a small amount of delta-9-tetrahydrocannabinol (from here on referred to as THC) which can be detected on a drug screening, however, in this instance the THC is one of the ingredients that help the body to absorb the many natural benefits of CBD, a prime example of the entourage effect. 

CBD topical products are an exception as these products only interact with cells at the application site, therefore not entering the bloodstream and passing through the liver, meaning they will not show up on a drug screen.

Some of the factors affecting the likelihood of full spectrum CBD being flagged on a drug test include, metabolism, frequency of dose, dosage, and method of testing. There are multiple testing methods used to detect drugs in the human body. Full spectrum CBD, if detected at all, is typically flagged on a “dip stick urine test” which separates molecules by weight. Given that THC and CBD have nearly identical molecular weights, CBD could be mistaken for THC on this type of test. There is a higher likelihood of CBD being detected if it was consumed within the 24-hour period prior to the test. A true toxicological blood test can distinguish the difference between CBD and THC.

An alternative to full spectrum CBD is CBD Isolate. CBD isolate is the CBD molecule separated from the rest of the hemp plant, which will have no trace of THC. However, CBD Isolate does not possess the entourage effect and therefore does not provide the same benefits as a full spectrum product. Some of those benefits include terpenes, flavonoids, vitamins and proteins which are all nutritional compounds that aid in overall wellness (“Does CBD Show Up on a Drug Test?,”2019). In addition, CBD Isolate products are highly processed and not natural.

Although CBD has not yet received FDA approval, here at Mt. Folly Farm where the hemp for Laura’s Mercantile products is grown, we work directly with Kentucky Congressional Delegation to ensure we are following all Federal regulations. Full-spectrum products are the most beneficial to consume, however, because there is a small chance that CBD products may be flagged on a drug test it is to your benefit to discuss with your HR department the required testing methods in order to prevent a false positive for THC that could cause problems with employment status. 

CBD has the ability to help people with multiple types of anxiety disorders. Several studies have been conducted to determine how CBD specifically combats anxiety. 

Initial studies on the anxiolytic impact of CBD were initially demonstrated on animals during the 1970s and 1980s, and later shown in humans with the Simulated Public Speaking Test. Results of this research revealed that CBD could improve social anxiety brought on by the test. 

More recent research has highlighted the potential roles of CBD in alleviating symptoms of anxiety across a variety of anxiety related disorders such as (Blessing, Steenkamp, Manzanares, & Marmar, 2015): 

Generalized anxiety disorder

Social anxiety disorder

Obsessive-compulsive disorder

Post-traumatic stress disorder

Panic disorder

Similarly to depression, CBD may mitigate anxiety through its impact on specific chemical systems of the brain. Imaging studies have been done that show CBD leads to patterns of activity that are consistent with the lowering of anxiety. In addition to its interaction with receptors in the brain, CBD may help anxiety by modifying cerebral blood flow (Zuardi, Garrido, et al, 2004). 

Like many other substances, full-spectrum CBD impacts our bodies largely by binding to proteins, or receptors, that are located on the surface of our cells. This binding initiates certain physiological responses occurring in the nervous system’s cannabinoid receptors, CB1 and CB2. 

However, unlike THC, which interacts more extensively with cannabinoid receptors, CBD does not appear to bind strongly to these receptors. Instead, it seems to achieve its effects by binding to other types of receptors, such as serotonin, which is known to influence things like pain, mood, and sleep. When it comes to the specifics of how CBD achieves its effects, the research surrounding epilepsy is the most thorough and provides the most information. It is because of this thorough research that the FDA approved a CBD drug for certain types of epilepsy (“FDA New Release,” 2018). 

A key finding in the case of epilepsy is the impact of CBD on the sodium channels of nerve cells. The movement of sodium in and out of these cells is often abnormal in epilepsy patients. This abnormal sodium movement can cause the brain cells to fire inappropriately leading to seizures. Scientists at Indiana University have shown that CBD can inhibit this problematic flow of sodium, reducing and minimizing seizures in epileptic patients. 

Research is continually being performed regarding the use of CBD in the treatment of Parkinson’s and Alzheimer’s disease. 

Parkinson’s disease is the second most common form of neurodegeneration associated with aging, trumped in prevalence only by Alzheimer’s disease. People with Parkinson’s undergo substantial changes to their endocannabinoid system – the system with which CBD interacts. Research indicates that CBD can alter some of these changes by using molecules which interact with receptors of the endocannabinoid system (“CBD for Parkinson’s,” 2019). 

Studies into this phenomenon have demonstrated that, of the many cannabinoids present in hemp, CBD appears to be among the most therapeutic in the context of Parkinson’s disease. In particular, it may be helpful in treating the non-motor symptoms of Parkinson’s disease. 

Preclinical investigations into opportunities for using CBD to treat other neurodegenerative disorders have shown that CBD can combat inflammation in models of Alzheimer’s disease. Other research on such models suggest that CBD may slow Alzheimer’s disease by reducing the activation of certain cells known as microglia. Because CBD can fight inflammation and oxidative stress, its capabilities with respect to protecting the brain from neurodegeneration continue to demand much attention from the medical research community(https://www.laurasmercantile.com/how-can-cbd-help-with-aging/). 

In summary, CBD is good for the brain by increasing cerebral blood flow, nerve cell regulation, and putting the endocannabinoid system in a state of homeostasis.  

There is not a significant amount of research in humans to identify the effects of consuming alcohol alongside CBD. 

The research that has been done (mostly in animals, such as mice) has identified that CBD may protect against alcohol induced cell damage while reducing blood alcohol concentrations (“What Happens If You Mix CBD and Alcohol”). This is not to say that taking CBD makes consuming a higher amount of alcohol safe, both of these substances should be consumed in moderation. Both CBD and alcohol have a sedation effect on the body and when taken together, these substances may amplify each other (“What Happens If You Mix CBD and Alcohol”). This amplification could make the consumer significantly impaired.

Terpenes are aromatic compounds found in plants, creating the fragrance found in plants like Lavender, pine, and hemp. These are the same compounds found in essential oils. Terpenes are beneficial for the plants as they either attract or repel insects. Attracting pollinators is crucial to the reproduction of many plant species and the same goes for keeping predators away. 

Studies have shown that terpenes may have many different beneficial properties (depending on the type of terpene). Ingesting or smelling these terpenes may have some of the following benefits in humans:

 

Anti-inflammatory

Antioxidant

Antiviral

Antidiabetic

Anticancer

Antimicrobial

Antidepressant

Neuroprotective

Antianxiety

(“What to know about terpenes,” 2020)

There are many different types of Terpenes and each varies in its terpene concentration and potential benefits. Research is continuing to be done to discover the wide variety of health benefits related to terpenes.

The color of CBD oil is dependent on a couple of factors and generally is a good way to tell what quality of product you are buying / looking at. CBD oil can range from a light gold color to an almost black or dark brown color. Generally speaking the darker the color, the more concentrated the product is. CBD Isolate or CBD by itself is an almost clear color. Full-spectrum CBD oil is a darker color as it is a more concentrated hemp extract. 

Factors affecting the color include the carrier oil, additional ingredients, and the methods of extraction. Additional ingredients tend to include added flavors which vary from brand to brand as well as different products within one brand. Some methods of extraction include, CO2 extraction, Steam distillation, hydrocarbon solvent extraction, and natural solvent extraction. 

Laura’s Mercantile CBD oil is golden in color and our product is as close to the natural plant as possible, meaning that they are full spectrum and contain the maximum amount of benefits. 

There are several factors that play into how long CBD will remain in your system including metabolism, BMI, frequency of CBD use, CBD dosage, and method of administration (sublingual vs. topical vs. edible). A slower metabolism will mean that it will take longer for the CBD to leave the system. The food in your digestive system at the time of ingestion can also affect the bioavailability in your body, meaning that certain foods can increase the absorption of CBD.

 Sublingual ingestion (placing a dose under the tongue) is considered to be more effective than ingestion. “Effective” in this scenario means a higher amount of absorption in a shorter period of time. 

There is still not enough research regarding the toxicology of CBD and how long it is detectable in blood or urine. Existing research indicates that CBD will most likely leave the system within 1-2 weeks. 

The FDA has not approved CBD oils at this time. But, the leadership at Laura’s Mercantile is currently working with the staff of Kentucky’s congressional delegation. Specifically, we are working with U.S. Senate Majority Leader McConnell’s staff to work with the FDA in order to follow policies and procedures for Laura’s Homestead Alternatives to be FDA compliant. 

We know now that SARS-CoV2 is spread through respiratory droplets produced when an infected person sneezes, coughs, shouts, talks expressively or sings. Since the early days of the pandemic, the air-borne nature of the virus has become clearer, and we’ve been instructed to wear masks when in public.

One idea floating around the hemp CBD community comes from a paper titled “In Search of Preventative Strategies: Novel Anti-inflammatory High CBD Cannabis Sativa Extracts Modulate ACE2 Expression in COVID-19 Gateway Tissues.” The basic idea is that COVID enters the body through the mouth or nose by binding with ACE2 receptors there. Since cannabinoids also bind with ACE2, theoretically they should block entry of the COVID virus. 

The paper and comments can be reviewed here.

There is one pre-publication review, written by Jordan Curl, who is a former Marine turned cannabis consultant, which I expect aims in the right direction. Here it is in its entirety:

“It is very interesting that this organization points out this was a high CBD extract from a chemovar of cannabis SATIVA. They say they screened 1000s of plants of which only a few had that characteristic. My guess is that they found some phenotype higher in “minor” cannabinoids and don’t want to say. Look at the analytics and they show THC/CBD only. Aside from being a blatant advertising plug, it also doesn’t factor in terpene content or other cannabinoids which are known to have synergistic effects together with THC and CBD.”

Curl is referring to the entourage effect, which we at Laura’s Homestead Alternatives think likely is a powerful one. Read more about the science here.

Because of this, we at Laura’s Homestead Alternatives only produce full-spectrum CBD, extracted from USDA-Certified, Mt. Folly grown organic hemp. Hemp plants contain more than 100 cannabinoids and terpenes. We trust the plant, trust nature, and are not trying to patent nature either!

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