A recent toxicology study conducted with CBD in mice concluded CBD can be detrimental to the liver at high doses. However, the study was conducted to find the upper limit of CBD’s toxicity, meaning the mice were essentially force-fed extremely high doses of an alcohol-based CBD product specifically to determine at what point CBD negatively impacted the mice.
It would be very difficult for a human to consume the same level of CBD to cause liver damage, and most CBD products on the market are not alcohol-based, which further minimizes risk of liver damage.
The caveat is CBD oil does interact with the liver in a such a way that it can reduce the effectiveness of other medications. A family of enzymes in the liver called cytochrome P450 break down drugs into smaller bits, allowing our cells to absorb and eliminate them. Although the impact has been shown to be minimal, CBD can reduce these enzymes’ abilities to metabolize some medications.